Cannabigerol Research:

Below is a list of current research publications aiming to show the potential therapeutic effects of CBG.

Studies:

• CBG was administered to rat’s on low dose of CBG can reduce fibrosis and inflammation in MCD-induced NASH, University of Northern Colorado: LINK
• CBD and CBG formulated appropriately exhibit anti-inflammatory activity. Our observations suggest that these non-psychoactive cannabinoids may have beneficial effects in treating diseases characterised by airway inflammation, Pulmonary Pharmacology & Therapeutics: LINK
• The presented data prove that all the examined cannabinoids exhibit antioxidant activity manifested in their ability to scavenge free radicals, to prevent the oxidation process and to reduce metal ions. Although the intensity of these activities is not the same for the individual cannabinoids it is comparable for all of them with that of E vitamin, Fitoterapia Volume 152: LINK
• To confirm these results and draw conclusions, the MTT assay would need to be repeated, and combined with the other assays. From this data, we may begin to hypothesize that 2 uM may be the most effective of increasing death/decreasing viability in E3 and EWD8 human breast cancer cells, University of Northern Colorado: LINK
• This review shows that CBD, CBG, and CBD+THC combination exert a predominantly anti-inflammatory effect in vivo, whereas THC alone does not reduce pro-inflammatory or increase anti-inflammatory cytokines. It is anticipated that this information could be used to inform human clinical trials of cannabinoids, focusing on CBD and CBG to reduce inflammation across a range of pathophysiological processes, Cannabis and Cannabinoid Research 2020: LINK
• BG-treated bacteria showed increased propidium iodide uptake and reduced calcein AM staining, suggesting that CBG increases the membrane permeability and reduces the metabolic activity. Furthermore, CBG prevented the drop in pH caused by the bacteria. In summary, we present here data showing the mechanisms by which CBG exerts its anti-bacterial effect against S. mutans, Frontiers In Microbiology 2021: LINK
• CBG and CBDV were protective against OG mediated injury in three different cells that constitute the BBB, modulating different hallmarks of ischemic stroke pathophysiology. These data enhance our understanding of the protective effects of CBG and CBDV and warrant further investigation into these compounds in ischemic stroke, Cannabis and Cannabinoid Research 2020: LINK
• Cannabinoid Combination Induces Cytoplasmic Vacuolation in MCF-7 Breast Cancer Cells, Department of Biochemistry and Microbiology, Nelson Mandela University: LINK